首页工具

登录

搜索结果

Search Results for " cc chemokine receptor "

36

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T11481	GSK2239633A	CCR	Immunology/Inflammation; Microbiology/Virology
	GSK2239633A 是趋化因子受体 CCR4 的变构拮抗剂，将 [125I]-TARC 与人 CCR4 结合的 pIC50 为 7.96。
T5384	RS 504393	CCR	Immunology/Inflammation; Microbiology/Virology
	RS 504393 是一种高度选择性的 CCR2 趋化因子受体拮抗剂，作用于人重组 CCR2 和 CCR1 受体，IC50值分别为 89 nM 和大于 100 μM。
TQ0283	RS102895	CCR	Immunology/Inflammation; Microbiology/Virology
	RS102895 是一种CCR2拮抗剂，IC50值为 360 nM。
T4300	AZD2098	CCR	Immunology/Inflammation; Microbiology/Virology
	AZD2098 是选择性CCR4抑制剂，可用于哮喘研究，对人类、大鼠、小鼠和狗的 CCR4 pIC50 值分别为 7.8、8.0、8.0和7.6。
T4674	SB297006 SB 297006	CCR	Immunology/Inflammation; Microbiology/Virology
	SB297006 是一种CCR3拮抗剂，IC50为39 nM。它能够显著抑制 CCL11 处理的神经祖细胞的增殖和神经球形成。
TQ0103	INCB3344	CCR	Immunology/Inflammation; Microbiology/Virology
	INCB3344 是一种有效、特异性和口服生物可利用的 CCR2 拮抗剂，结合拮抗作用的 IC50 值为 9.5 nM (mCCR2) 和 5.1 nM (hCCR2)，趋化活性拮抗作用的 IC50 值为 7.8 nM (mCCR2) 和 3.8 nM (hCCR2)。
T30258	AZD-4818 CCR1 antagonist	CCR	Immunology/Inflammation; Microbiology/Virology
	AZD-4818 (CCR1 antagonist) 是趋化因子CCR1的一种拮抗剂，可用于研究慢性阻塞性肺病。
T24700	R243 R 243,R-243	CCR	Immunology/Inflammation; Microbiology/Virology
	R243 是选择性的CCR8拮抗剂，可抑制CCL1/CCR8的相互作用，以及CCR8信号传导和趋化性，具有抗伤害感受和抗炎作用。
T7499	TAK-779 Takeda 779	HIV Protease; CXCR; CCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	TAK-779 (Takeda 779) 是一种非肽类CCR5和CXCR3 拮抗剂，对CCR5的Ki 值为 1.1 nM，并选择性抑制R5 HIV-1。
T10425	AZ084	CCR	Immunology/Inflammation; Microbiology/Virology
	AZ084 是可口服的选择性 CCR8变构拮抗剂，其Ki 值为 0.9 nM，可研究哮喘。
T16111	ML604086	CCR	Immunology/Inflammation; Microbiology/Virology
	ML604086 是选择性CCR8抑制剂，抑制循环T 细胞上 CCL1 与 CCR8 结合，还抑制 CCL1 介导的趋化性并提高细胞内 Ca2 浓度。
T16091	MK-0812 Succinate	Others; CCR	Immunology/Inflammation; Microbiology/Virology; Others
	MK-0812 Succinate 是一种选择性CCR2拮抗剂。
T11699	J-113863	CCR	Immunology/Inflammation; Microbiology/Virology
	J-113863 是选择性的 CCR1 (CD18)拮抗剂，有抗炎作用，对人和小鼠 CCR1受体的 IC50值分别为 0.9 和 5.8 nM。它是人 CCR3的强效拮抗剂，还是小鼠 CCR3的弱效拮抗剂，IC50分别为 0.58 和 460 nM。
T4584	BMS-813160 BMS 813160	CCR	Immunology/Inflammation; Microbiology/Virology
	BMS-813160 是CCR2/CCR5双重拮抗剂。有用于心血管的研究潜力。
T12773	RS102895 hydrochloride RS102895盐酸盐	Others; 5-HT Receptor; CCR	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Others
	RS102895 hydrochloride 是一种CCR2拮抗剂，IC50值为 360 nM。
T3430	PF-4136309 INCB8761,PF 4136309	CCR	Immunology/Inflammation; Microbiology/Virology
	PF-4136309 (INCB8761) 是一种高效选择性和可口服的 CCR2拮抗剂，能够抑制人、小鼠和大鼠 CCR2，IC50值分别为 5.2、17 和 13 nM。
T2375	BX471 BX 471,BX-471,ZK-811752	CCR	Immunology/Inflammation; Microbiology/Virology
	BX471 (BX 471) 是可口服的非多肽 CCR1选择性拮抗剂，Ki 值为 1 nM，对其选择性是对 CCR2、CCR5 和 CXCR4 的 250 倍。
T17225	Vercirnon CCX282-B,维塞诺,GSK-1605786,Traficet-EN	CCR	Immunology/Inflammation; Microbiology/Virology
	Vercirnon (Traficet-EN) 是可口服的选择性 CCR9拮抗剂，可抑制 CCR9 介导的 Molt-4 细胞上 Ca2+移动和趋化性，用于炎症性肠病的研究。
T10639	C-021 dihydrochloride	CCR	Immunology/Inflammation; Microbiology/Virology
	C-021 dihydrochloride 是一种有效的 CCR4 拮抗剂。它有效抑制人和小鼠的功能趋化性，IC50 为 140 nM 和 39 nM。
T6016	Maraviroc Celsentri,马拉维若,UK-427857,Selzentry	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Maraviroc (Selzentry) 是一种 C-C 趋化因子受体 5 拮抗剂，具有抑制HIV 的活性。
T7624	DAPTA DAPTA(TFA),D-Ala-peptide T-amide,Adaptavir	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	DAPTA (Adaptavir) 是一种合成肽，是 CCR5抑制剂，有抗 HIV 的活性。
TQ0297	Cenicriviroc TAK-652,TBR-652	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Cenicriviroc (TAK-652) 是一种可口服的CCR2/CCR5拮抗剂，可抑制 HIV-1 和 HIV-2，具有抗炎、抗感染作用。
T13114	CCR2 antagonist 4 Teijin compound 1	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR2 antagonist 4 (Teijin compound 1) 是高效的、特异性的CCR2拮抗剂，对 CCR2b 的IC50为 180 nM，抑制 MCP-1 诱导的趋化作用的 IC50为 24 nM。
T21870	C-021 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-	CCR	Immunology/Inflammation; Microbiology/Virology
	C 021 dihydrochloride 是一种 CC 趋化因子受体 4 (CCR4) 拮抗剂，抑制人和小鼠的功能趋化性，IC50分别为 140 和 39 nM。C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) 可有效阻止人 CCL22 衍生的 [35S]GTPγS 与受体结合，IC50为 18 nM。
T14900	CCR2-RA-[R] (5R)-4-乙酰基-1-(4-氯-2-氟苯基)-5-环己基-1,5-二氢-3-羟基-2H-吡咯-2-酮	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR2-RA-[R] 是一种 C-C 趋化因子受体 2 型 (CCR2) 变构拮抗剂，IC50值为103 nM。
T3435	Vicriviroc maleate 维立韦罗马来酸盐,SCH-D (maleate),SCH-417690 (maleate)	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Vicriviroc maleate (SCH-417690 (maleate)) 是一种可口服，可透过血脑屏障的 CCR5选择性拮抗剂，同时抑制外周血单核细胞中的 HIV-1 的活性。
T2386	Pirfenidone S-7701,AMR-69,S-7701,AMR69,吡非尼酮	CCR; TGF-beta/Smad	Immunology/Inflammation; Microbiology/Virology; Stem Cells
	Pirfenidone (AMR69) 是一种抗纤维化剂，可减弱纤维细胞中CCL2和CCL12的产生。它可抑制细胞生长，并能降低人胶质瘤细胞系中的TGF-β2蛋白水平，具有抗炎活性。
T76782	Mogamulizumab KW-0761	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Mogamulizumab (KW-0761) 是一种针对 T 细胞 CC 趋化因子受体 4 的单克隆抗体。Mogamulizumab 具有抗癌活性，通过抗体依赖性细胞毒性 (ADCC) 消除肿瘤细胞，可用于研究癌症、成人T细胞白血病/淋巴瘤 (ATLL)、皮肤T细胞淋巴瘤(CTCL)。
T68984	AF-399/42018025
	AF-399/42018025 is a CC chemokine receptor 4 (CCR4) antagonist.
T29181	YM-355179 YM 355179
	YM-355179 is a novel, selective antagonist of CC chemokine receptor 3 with oral activity.
T69830	GSK2239633
	GSK2239633 is a potent CC-chemokine receptor 4 antagonist with pIC50 of 7.9. The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2 T-helper lymphocytes to the inflamed airways. Therefore, CCR4 provides an excellent target for anti-inflammatory therapy.
T26642	Aplaviroc hydrochloride AK602,AK 602,GW873140A,GW-873140,GW873140,AK-602,Aplaviroc HCl
	Aplaviroc is a human cellular CC chemokine receptor 5 (CCR5) entry inhibitor. Aplaviroc binds specifically to CCR5 and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc
T10716	CCR7 Ligand 1 CCR7-Cmp2105	Others	Others
	CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM
T10713	CCR4 antagonist 2	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.
T69523	BMS-681
	BMS-681 is an orthosteric antagonist of chemokine receptor 2 (CCR2) that forms a ternary complex with CCR2 and its allosteric antagonist, CCR2-RA-[R]. Together, the complex inhibits chemokine binding with BVMS-681 in the orthosteric pocket and CCR2-RA-[R] in the intracellular allosteric G-protein binding site. When chemokine binding is inhibited, modulation responses implicated in several inflammatory and neurodegenerative diseases, including atherosclerosis, multiple sclerosis, asthma, neuropat...
T69081	KRH-1636
	KRH-1636 is an orally active, selective and extremely potent CXC chemokine receptor 4 antagonist. KRH-1636 exhibits a potent and selective anti-HIV-1 activity. KRH-1636 efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXC chemokine receptor (CXCR)4 coreceptor but not via CC chemokine receptor 5. KRH-1636 also inhibits binding of the CXC chem...

化合物

Cat.No: T11481

Target: CCR

Cat.No: T5384

Target: CCR

Cat.No: TQ0283

Target: CCR

Cat.No: T4300

Target: CCR

Cat.No: T4674

Synonym: SB 297006

Target: CCR

Cat.No: TQ0103

Target: CCR

Cat.No: T30258

Synonym: CCR1 antagonist

Target: CCR

Cat.No: T24700

Synonym: R 243,R-243

Target: CCR

Cat.No: T7499

Synonym: Takeda 779

Target: HIV Protease, CXCR, CCR

Cat.No: T10425

Target: CCR

Cat.No: T16111

Target: CCR

MK-0812 Succinate

Cat.No: T16091

Target: Others, CCR

Cat.No: T11699

Target: CCR

Cat.No: T4584

Synonym: BMS 813160

Target: CCR

RS102895 hydrochloride

Cat.No: T12773

Synonym: RS102895盐酸盐

Target: Others, 5-HT Receptor, CCR

Cat.No: T3430

Synonym: INCB8761,PF 4136309

Target: CCR

Cat.No: T2375

Synonym: BX 471,BX-471,ZK-811752

Target: CCR

Cat.No: T17225

Synonym: CCX282-B,维塞诺,GSK-1605786,Traficet-EN

Target: CCR

C-021 dihydrochloride

Cat.No: T10639

Target: CCR

Cat.No: T6016

Synonym: Celsentri,马拉维若,UK-427857,Selzentry

Target: HIV Protease, CCR

Cat.No: T7624

Synonym: DAPTA(TFA),D-Ala-peptide T-amide,Adaptavir

Target: HIV Protease, CCR

Cat.No: TQ0297

Synonym: TAK-652,TBR-652

Target: HIV Protease, CCR

CCR2 antagonist 4

Cat.No: T13114

Synonym: Teijin compound 1

Target: CCR

Cat.No: T21870

Synonym: 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-

Target: CCR

Cat.No: T14900

Synonym: (5R)-4-乙酰基-1-(4-氯-2-氟苯基)-5-环己基-1,5-二氢-3-羟基-2H-吡咯-2-酮

Target: CCR

Vicriviroc maleate

Cat.No: T3435

Synonym: 维立韦罗马来酸盐,SCH-D (maleate),SCH-417690 (maleate)

Target: HIV Protease, CCR

Cat.No: T2386

Synonym: S-7701,AMR-69,S-7701,AMR69,吡非尼酮

Target: CCR, TGF-beta/Smad

Cat.No: T76782

Synonym: KW-0761

Target: CXCR

AF-399/42018025

Cat.No: T68984

Cat.No: T29181

Synonym: YM 355179

Cat.No: T69830

Aplaviroc hydrochloride

Cat.No: T26642

Synonym: AK602,AK 602,GW873140A,GW-873140,GW873140,AK-602,Aplaviroc HCl

Cat.No: T10716

Synonym: CCR7-Cmp2105

Target: Others

CCR4 antagonist 2

Cat.No: T10713

Target: Calcium Channel

Cat.No: T69523

Cat.No: T69081

Cat. No.	Product Name	Target	Signaling Pathways
T6413	Bindarit 宾达利,AF2838	CCR	Immunology/Inflammation; Microbiology/Virology
	Bindarit (AF2838) 是单核细胞趋化蛋白MCP-1/CCL2，MCP-3/CCL7和MCP-2/CCL8的选择性抑制剂，具有抗炎作用。
TN1273	7,4'-Dihydroxyflavone 4',7-Dihydroxyflavone,7,4'-二羟基黄酮	NF-κB; COX; HDAC; CCR; NOD	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) 是从甘草中分离的类黄酮，是 eotaxin/CCL11抑制剂，抑制嗜酸性粒细胞趋化因子产生。它通过调节 NF-κB、STAT6 和 HDAC2，抑制 MUC5A 基因表达和粘液产生。

天然产物

Cat.No: T6413

Synonym: 宾达利,AF2838

Target: CCR

7,4'-Dihydroxyflavone

Cat.No: TN1273

Synonym: 4',7-Dihydroxyflavone,7,4'-二羟基黄酮

Target: NF-κB, COX, HDAC, CCR, NOD

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼